The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.27683
Abstract: The mammalian target of rapamycin is an enzyme that regulates cell metabolism and proliferation. It is up‐regulated in aggressive tumors, such as glioblastoma, leading to increased glucose uptake and consumption. It has been suggested that… read more here.
Keywords: effect mtor; inhibitor rapamycin; mtor inhibitor; rapamycin glucocest ... See more keywords
Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81482-3
Abstract: Determine the impact of the mTOR inhibitor, rapamycin, on the hyperglycemia-induced expression of vascular endothelial growth factor (VEGF) and the production of reactive oxygen species (ROS) in retinal cells. Rats made hyperglycemic for 8 weeks… read more here.
Keywords: inhibitor rapamycin; mtor inhibitor; hyperglycemia induced; induced vegf ... See more keywords