DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.06.036
Abstract: The bromodomain and extra-terminal domain (BET) protein BRD4 is emerging as a promising anticancer therapeutic target. However, resistance to BET inhibitors often occurs, and it has been linked to aberrant degradation of BRD4 protein in… read more here.
Keywords: cancer; dub3; inhibitor resistance; bet inhibitor ... See more keywords
Characterization of Acetolactate Synthase (ALS)-Inhibitor Resistance in Pennsylvania Smartweed (Persicaria pensylvanica)
Sign Up to like & getrecommendations! Published in 2018 at "Weed Science"
DOI: 10.1017/wsc.2018.44
Abstract: Abstract Pennsylvania smartweed [Persicaria pensylvanica (L.) M. Gómez] is a common weed of rice (Oryza sativa L.) in the midsouthern United States and has recently become a concern for farmers because of reduced tillage systems.… read more here.
Keywords: smartweed persicaria; persicaria pensylvanica; als inhibitor; resistance ... See more keywords
Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs
Sign Up to like & getrecommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-025-02180-4
Abstract: Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (Her2−) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI3K inhibitor Alpelisib. This… read more here.
Keywords: inhibitor resistance; breast cancer; inhibitor; pi3k inhibitor ... See more keywords
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20220461
Abstract: Chk1 is a member of the DNA damage response pathway, whose loss leads to replication stress and genome instability. Because of its protective role against lethal levels of DNA replication stress, Chk1 has been studied… read more here.
Keywords: inhibitor resistance; mechanisms chk1; chk1; chk1 inhibitor ... See more keywords
Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220134120
Abstract: Significance Using combinatorial loss-of-function CRISPR screens, our study revealed a Bromo- and extra-terminal domain inhibitors (BETi) resistance network in KMT2A-r leukemia. Based on these findings, we have also revealed a corresponding synergy treatment regimen, significantly… read more here.
Keywords: inhibitor resistance; crispr screens; interrogating bromodomain; resistance ... See more keywords
Multiple initiatives to conquer KRAS G12C inhibitor resistance from the perspective of clinical therapy
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2023.2178419
Abstract: ABSTRACT Introduction KRAS G12C targeted covalent inhibitors for cancer therapy are revolutionary. However, resistance to KRAS G12C inhibitors in clinical trials is a proven fact. Areas covered The authors focus on providing coverage and emphasizing… read more here.
Keywords: kras g12c; inhibitor resistance; therapy; resistance ... See more keywords
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1744980
Abstract: ABSTRACT ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we… read more here.
Keywords: inhibitor resistance; adam10 adam17; adam17 cleave; adam10 ... See more keywords
Prevalence of Naturally Occurring HIV-1 Capsid Inhibitor Resistance–Related Mutations in Antiretroviral Therapy–Naïve and –Experienced Individuals in Taiwan
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaf028
Abstract: Abstract Background It is generally believed that HIV-1 capsid inhibitor–naïve populations are susceptible to capsid inhibitors. Moreover, conventional HIV-1 resistance genotyping does not include the CA region, leading to limited surveillance data. Methods We conducted… read more here.
Keywords: capsid inhibitor; inhibitor resistance; capsid; hiv ... See more keywords
Heterogeneous alteration of the ERBB3–MYC axis associated with MEK inhibitor resistance in a KRAS-mutated low-grade serous ovarian cancer patient
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a004341
Abstract: Low-grade serous ovarian cancer (LGSOC) is relatively chemoresistant, and no precision therapy is approved for this indication. Despite promising results in phase II trials, MEK inhibitors have failed to show improved progression-free survival in a… read more here.
Keywords: kras mutated; inhibitor; mek inhibitor; inhibitor resistance ... See more keywords
Exosomes mediate intercellular transfer of non–autonomous tolerance to proteasome inhibitors in mixed‐lineage leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14351
Abstract: Proteasome inhibitors significantly improve cancer outcomes, but their use is eventually followed by proteasome inhibitor resistance and relapse. Current understanding of proteasome inhibitor resistance is limited to cell‐autonomous mechanisms; whether non–autonomous mechanisms can be implicated… read more here.
Keywords: proteasome inhibitor; inhibitor resistance; inhibitor; mixed lineage ... See more keywords
Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aao4307
Abstract: Chronic stress hormones promote EGFR inhibitor resistance in EGFR mutant non–small cell lung cancer. Destressing cancer with β-blockers Common wisdom holds that stress is not good for cancer patients, but it can be difficult to… read more here.
Keywords: stress hormones; egfr inhibitor; resistance; cancer ... See more keywords