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Published in 2017 at "MedChemComm"
DOI: 10.1039/c6md00643d
Abstract: Mitoxantrone, an FDA-approved drug for multiple sclerosis and hormone refractory prostate cancer, is identified as a potent inhibitor of ROS1 fusion protein by in silico screening in non-small cell lung cancer cells. Mitoxantrone can suppress…
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Keywords:
ros1 fusion;
inhibitor ros1;
ros1;
cancer ... See more keywords
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Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-22-0968
Abstract: NVL-520, a selective macrocyclic inhibitor of ROS1, demonstrated antitumor activity in patient case studies of ROS1 inhibitor–refractory lung cancers without observed neurologic toxicities attributed to TRK inhibition.
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Keywords:
inhibitor ros1;
nvl 520;
selective trk;
520 selective ... See more keywords