Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome
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DOI: 10.1002/cbic.201700021
Abstract: Selective inhibition of the immunoproteasome is a promising approach towards the development of immunomodulatory drugs. Recently, a class of substituted thiazole compounds that combine a nonpeptidic scaffold with the absence of an electrophile was reported… read more here.
Keywords: human immunoproteasome; nonpeptidic inhibitor; elucidation nonpeptidic; structural elucidation ... See more keywords
An aggregation inhibitor specific to oligomeric intermediates of Aβ42 derived from phage display libraries of stable, small proteins
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DOI: 10.1073/pnas.2121966119
Abstract: Significance Alzheimer’s disease affects a growing number of people, but a cure is lacking. The disease is connected to the formation of plaques in the brain, the first of which appear years before the first… read more here.
Keywords: inhibitor specific; intermediates derived; derived phage; specific oligomeric ... See more keywords