A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation
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DOI: 10.1073/pnas.2220012120
Abstract: Significance We have used an established in vitro cyclic peptide selection strategy to generate a novel inhibitor of multidrug resistance protein 1 (MRP1), an ABC transporter implicated in cancer drug resistance. Multiple small-molecule MRP1 inhibitors… read more here.
Keywords: inhibitor traps; inhibitor; peptide; peptide inhibitor ... See more keywords