Unexpected Biotransformation of the HDAC Inhibitor Vorinostat Yields Aniline-Containing Fungal Metabolites.
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DOI: 10.1021/acschembio.7b00268
Abstract: The diversity of genetically encoded small molecules produced by filamentous fungi remains largely unexplored, which makes these fungi an attractive source for the discovery of new compounds. However, accessing their full chemical repertoire under common… read more here.
Keywords: aniline containing; vorinostat; inhibitor vorinostat; hdac inhibitor ... See more keywords
Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency
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DOI: 10.1172/jci92684
Abstract: BACKGROUND. The histone deacetylase (HDAC) inhibitor vorinostat (VOR) can increase HIV RNA expression in vivo within resting CD4+ T cells of aviremic HIV+ individuals. However, while studies of VOR or other HDAC inhibitors have reported… read more here.
Keywords: latency; vor; hdac inhibitor; hiv latency ... See more keywords