Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome
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DOI: 10.1021/acscentsci.9b01170
Abstract: We have developed a syringolin-based chemical probe and explored its utility for the profiling of metabolite extracts as potent inhibitors of the 20S proteasome. Activity-guided fractionation by competitive labeling allowed us to isolate and identify… read more here.
Keywords: natural products; inhibitors 20s; competitive metabolite; profiling natural ... See more keywords