Novel Inhibitors and Activity-Based Probes Targeting Trypsin-Like Serine Proteases
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DOI: 10.3389/fchem.2022.782608
Abstract: The trypsin-like proteases (TLPs) play widespread and diverse roles, in a host of physiological and pathological processes including clot dissolution, extracellular matrix remodelling, infection, angiogenesis, wound healing and tumour invasion/metastasis. Moreover, these enzymes are involved… read more here.
Keywords: novel inhibitors; inhibitors activity; activity; activity based ... See more keywords
Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-N-Oxide Derivatives
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DOI: 10.3390/molecules24132348
Abstract: Infections caused by Fasciola species are widely distributed in cattle and sheep causing significant economic losses, and are emerging as human zoonosis with increasing reports of human cases, especially in children in endemic areas. The… read more here.
Keywords: quinoxaline oxide; activity liver; oxide derivatives; inhibitors activity ... See more keywords