Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
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DOI: 10.1021/acs.jmedchem.0c00347
Abstract: Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase IV. Increasing rates of resistance,… read more here.
Keywords: topoisomerase inhibitors; gram negative; topoisomerase; resistance ... See more keywords