Development of PI3K inhibitors: advances in clinical trials and new strategies (Review).
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DOI: 10.1016/j.phrs.2021.105900
Abstract: Phosphatidylinositol 3-kinases (PI3Ks) are the family of vital lipid kinases widely distributed in mammalian cells. The overexpression of PI3Ks leads to hyperactivation of the PI3K/AKT/mTOR pathway, which is considered a pivotal pathway in the occurrence… read more here.
Keywords: pi3k; development pi3k; inhibitors advances; clinical trials ... See more keywords