Covalent allosteric inhibitors of Akt generated using a click fragment approach.
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DOI: 10.1002/cmdc.202100776
Abstract: Akt is a protein kinase that has been implicated in the progression of cancerous tumors. A number of covalent allosteric Akt inhibitors are known, and based on these scaffolds, a small library of novel potential… read more here.
Keywords: covalent; allosteric inhibitors; covalent allosteric; inhibitors akt ... See more keywords