Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases.
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DOI: 10.1021/acs.biochem.9b00774
Abstract: The α-ketoglutarate-dependent (AlkB) superfamily of FeII/2-oxoglutarate (2-OG) -dependent dioxygenases consists of a unique class of nucleic acid repair enzymes which reversibly remove alkyl substituents from nucleobases through oxidative dealkylation. Recent studies have verified the involvement… read more here.
Keywords: family nucleic; alkb family; inhibitors alkb; selective inhibitors ... See more keywords