Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disorders
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03178-2
Abstract: As life expectancy increases worldwide, age-related neurodegenerative diseases will increase in parallel. The lack of effective treatment strategies may soon lead to an unprecedented health, social and economic crisis. Any attempt to halt the progression of these diseases… read more here.
Keywords: alzheimer disease; tissue inhibitors; disease; inhibitors alzheimer ... See more keywords
Design, synthesis, in vitro and in vivo evaluation of tacrine–cinnamic acid hybrids as multi-target acetyl- and butyrylcholinesterase inhibitors against Alzheimer's disease
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DOI: 10.1039/c7ra04385f
Abstract: Previously, we have reported tacrine–ferulic acid hybrids as multi-target cholinesterase inhibitors against Alzheimer's disease. However, the detailed structure–activity relationship (SAR), especially regarding the ferulic acid moiety, has yet to be elucidated. Herein we report the… read more here.
Keywords: hybrids multi; alzheimer disease; inhibitors alzheimer; acid hybrids ... See more keywords
BACE1 Inhibitors for Alzheimer’s Disease: The Past, Present and Any Future?
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DOI: 10.3390/molecules27248823
Abstract: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the most common cause of dementia in the elderly. The complexity of AD has hindered the development of either a cure or a disease-modifying therapy… read more here.
Keywords: bace1 inhibitors; disease; alzheimer disease; inhibitors alzheimer ... See more keywords