Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180214111849
Abstract: Endoplasmic Reticulum aminopeptidase 1 and 2 are two homologous enzymes that help generate peptide ligands for presentation by Major Histocompatibility Class I molecules. Their enzymatic activity influences the antigenic peptide repertoire and indirectly controls adaptive… read more here.
Keywords: aminopeptidase design; chemistry; inhibitors aminopeptidase; design clinical ... See more keywords
IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.585930
Abstract: The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total… read more here.
Keywords: inspiration; irap inhibitors; aminopeptidase family; irap ... See more keywords