Revisiting mTOR inhibitors as anticancer agents.
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DOI: 10.1016/j.drudis.2019.05.030
Abstract: The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates a variety of cellular processes, influencing diverse pathological conditions including a variety of cancers. Accordingly, therapies that target mTOR as anticancer… read more here.
Keywords: mtor inhibitors; anticancer agents; mtor; revisiting mtor ... See more keywords
Fibroblast growth factor receptor (FGFR) inhibitors as anticancer agents: 3D-QSAR, molecular docking and dynamics simulation studies of 1, 6-naphthyridines and pyridopyrimidines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2053206
Abstract: Abstract Fibroblast growth factor receptor (FGFR) plays a vital role in tissue regeneration, angiogenesis, and embryogenesis. 3D-QSAR and molecular modeling methods are widely used for designing novel compounds for the determination of inhibitory activity against… read more here.
Keywords: receptor fgfr; factor receptor; growth factor; inhibitors anticancer ... See more keywords
Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018)
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DOI: 10.1080/13543776.2019.1623880
Abstract: ABSTRACT Introduction: COX-2 is a key enzyme in the process of prostaglandins (PGs) synthesis. The products of this enzyme could play a major role as the mediators of the inflammatory response and some other medical… read more here.
Keywords: selective cox; anticancer agents; cox inhibitors; cox ... See more keywords
Natural-derived COX-2 inhibitors as Anticancer Drugs: A Review of Their Structure Diversity and Mechanism of Action.
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DOI: 10.2174/1389450123666220516153915
Abstract: Cyclooxygenase-2 (COX-2) is a key-type enzyme playing a crucial role in cancer development, making it a target of high interest for drug designers. In the last two decades, numerous selective COX-2 inhibitors have been approved… read more here.
Keywords: cox inhibitors; structure; cox; natural derived ... See more keywords
Recent Progress in Histone deacetylase (HDAC) 1 Inhibitors as Anticancer Agent.
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DOI: 10.2174/1568009622666220624090542
Abstract: Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing histone deacetylation. Aberrant expression of HDACs is associated with various human diseases. Although HDAC inhibitors are used as effective chemotherapeutic agents in clinical practice, their… read more here.
Keywords: hdac1 inhibitors; histone; hdac inhibitors; hdac1 ... See more keywords
Computational modelling strategies in exploring triazolopyridazine PIM1 kinase inhibitors as anticancer agents.
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DOI: 10.2174/1871520622666220820090353
Abstract: BACKGROUND PIM (Proviral Integration site for Moloney Murine Leukemia virus) kinases are members of the class of kinase family serine/ threonine kinases, which play a crucial role in cancer development. As there is no drug… read more here.
Keywords: kinase inhibitors; kinase; inhibitors anticancer; drug ... See more keywords