Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin
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DOI: 10.1002/cmdc.201800446
Abstract: Acylhydrazoneâbased dynamic combinatorial chemistry (DCC) is a powerful strategy for the rapid identification of novel hits. Even though acylhydrazones are important structural motifs in medicinal chemistry, their further progression in development may be hampered by… read more here.
Keywords: design synthesis; bioisosteres acylhydrazones; protease endothiapepsin; chemistry ... See more keywords