Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
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DOI: 10.1073/pnas.1812963116
Abstract: Significance Mutants of RAS are major oncogenes and occur in many human cancers, but efforts to develop drugs that directly inhibit the corresponding constitutively active RAS proteins have failed so far. We therefore focused on… read more here.
Keywords: inhibitors block; sos1; interaction; sos1 interaction ... See more keywords