PI3K Inhibitors in Breast Cancer Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Current Oncology Reports"
DOI: 10.1007/s11912-019-0846-7
Abstract: The phosphatidylinositol 3-kinase (PI3K) pathway is the most common aberrantly activated pathway in breast cancer, making it an attractive therapeutic target. In this review, we will discuss the rationale for targeting PI3K/AKT signaling and the… read more here.
Keywords: cancer; inhibitors breast; pi3k inhibitors; breast cancer ... See more keywords
[PARP inhibitors in breast cancer: Current clinical development and perspectives].
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2020.07.011
Abstract: The association of a germline mutation in the BRCA1/2 genes in breast cancer leads to a higher genomic instability and, thus, a potential higher sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. In this review, we will summarize… read more here.
Keywords: parp inhibitors; cancer current; inhibitors breast; breast cancer ... See more keywords
Integrated bioinformatics, computational and experimental methods to discover novel Raf/extracellular-signal regulated kinase (ERK) dual inhibitors against breast cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.009
Abstract: Beginning with our previously reported ERK inhibitor BL-EI001, we found Raf1 to be an important regulator in the ERK interactive network, and then we designed and synthesized a novel series of Raf1/ERK dual inhibitors against… read more here.
Keywords: inhibitors breast; erk; breast cancer; dual inhibitors ... See more keywords
The efficacy and safety of PD-1/PD-L1 inhibitors in breast cancer: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Translational cancer research"
DOI: 10.21037/tcr-19-3020
Abstract: Despite 5-year overall survival rate of breast cancer was 90%, approximately 30% breast cancer patients with an early-stage diagnosis eventually progressed to advanced metastatic disease, and about 6% of patients were metastatic disease at diagnosis… read more here.
Keywords: safety inhibitors; efficacy safety; inhibitors breast; breast cancer ... See more keywords
The Evolutionary Tale and Future Directions of Aromatase Inhibitors in Breast Carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520617666170327114831
Abstract: Aromatase inhibitors have often been likened to that of 'medical scalpels' for the treatment of breast carcinoma. By inhibiting the singular step of aromatisation, they have proven to be extremely effective allies in the treatment… read more here.
Keywords: inhibitors breast; aromatase inhibitors; treatment breast; breast carcinoma ... See more keywords