Tetrahydroindazole inhibitors of CDK2/cyclin complexes.
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DOI: 10.1016/j.ejmech.2021.113232
Abstract: Over 50 tetrahydroindazoles were synthesized after 7-bromo-3,6,6-trimethyl-1-(pyridin-2-yl)-5,6,7,7a-tetrahydro-1H-indazol-4(3aH)-one (3) was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogues… read more here.
Keywords: inhibitors cdk2; tetrahydroindazole inhibitors; cyclin; cdk2 cyclin ... See more keywords