Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy in Patients With Metastatic Colorectal Cancer With Measures of Microsatellite Instability, Mismatch Repair, or Tumor Mutational Burden
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DOI: 10.1001/jamanetworkopen.2022.52244
Abstract: This comparative effectiveness research study compares outcomes of first-line therapy with immune checkpoint inhibitors vs chemotherapy among patients who have metastatic colorectal cancer with high microsatellite instability, mismatch repair deficiency, and/or high tumor mutational burden. read more here.
Keywords: checkpoint inhibitors; immune checkpoint; metastatic colorectal; inhibitors chemotherapy ... See more keywords
The Efficacy of Immune Checkpoint Inhibitors vs. Chemotherapy for KRAS-Mutant or EGFR-Mutant Non-Small-Cell Lung Cancers: A Meta-Analysis Based on Randomized Controlled Trials
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DOI: 10.1155/2022/2631852
Abstract: Objective To assess and compare the effectiveness of immune checkpoint inhibitors vs. chemotherapy for KRAS-mutant or EGFR-mutant non-small-cell lung cancers. Methods Until February 19, 2022, Cochrane Library, PubMed, Web of Science, and Embase were searched… read more here.
Keywords: cell; checkpoint inhibitors; inhibitors chemotherapy; immune checkpoint ... See more keywords
Clinical outcomes of non-small cell lung cancer brain metastases treated with stereotactic radiosurgery and immune checkpoint inhibitors, EGFR tyrosine kinase inhibitors, chemotherapy and immune checkpoint inhibitors, or chemotherapy alone.
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DOI: 10.3171/2022.9.jns221896
Abstract: OBJECTIVE Immune checkpoint inhibitors (ICIs) and epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are commonly used in the systemic management of non-small cell lung cancer (NSCLC) brain metastases (BMs). However, optimizing control of NSCLC BM… read more here.
Keywords: checkpoint inhibitors; immune checkpoint; chemotherapy alone; inhibitors chemotherapy ... See more keywords
Pathologic response and safety to neoadjuvant PD-1 inhibitors and chemotherapy in resectable squamous non-small-cell Lung cancer
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DOI: 10.3389/fonc.2022.956755
Abstract: Background Several randomized studies have shown that the combination of programmed cell death 1 (PD-1) inhibitor and chemotherapy is efficacious as a treatment for advanced non-small-cell lung cancer (NSCLC). However, in the neoadjuvant setting, there… read more here.
Keywords: resectable squamous; squamous nsclc; inhibitors chemotherapy; chemotherapy resectable ... See more keywords