Design, Synthesis, and Bioevaluation of Indole Core Containing 2-Arylidine Derivatives of Thiazolopyrimidine as Multitarget Inhibitors of Cholinesterases and Monoamine Oxidase A/B for the Treatment of Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06344
Abstract: In continuation of our previous study to identify multitarget inhibitors of cholinesterases (ChEs) and monoamine oxidase (MAOs) isoforms, we synthesized and evaluated 2-arylidine derivatives of thiazolopyrimidine for the treatment of Alzheimer disease. Three series of… read more here.
Keywords: multitarget inhibitors; multitarget; monoamine oxidase; arylidine derivatives ... See more keywords
Chalcones acting as inhibitors of cholinesterases, β-secretase and βamyloid aggregation and other targets for Alzheimer's disease: a critical review.
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DOI: 10.2174/0929867327666201020151804
Abstract: BACKGROUND Alzheimer's disease (AD) is an irreversible and progressive neurodegeneration, with a multifactorial pathophysiology, including cholinergic deficit, amyloid plaques, neurofibrillary tangles, oxidative stress, and neurodegeneration. Despite the severity of the disease, the therapeutic arsenal is… read more here.
Keywords: acting inhibitors; alzheimer disease; chalcones acting; review ... See more keywords
Natural Inhibitors of Cholinesterases: Chemistry, Structure–Activity and Methods of Their Analysis
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DOI: 10.3390/ijms24032722
Abstract: This article aims to provide an updated description and comparison of the data currently available in the literature (from the last 15 years) on the studied natural inhibitors of cholinesterases (IChEs), namely, acetylcholinesterase (AChE) and… read more here.
Keywords: structure activity; chemistry; natural inhibitors; activity ... See more keywords
N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases
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DOI: 10.3390/molecules27217437
Abstract: Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical features of… read more here.
Keywords: derivatives ferulic; hydroxy propargylamide; acid inhibitors; inhibitors cholinesterases ... See more keywords
Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches
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DOI: 10.3390/nu13010254
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease conceptualized as a clinical-biological neurodegenerative construct where amyloid-beta pathophysiology is supposed to play a role. The loss of cognitive functions is mostly characterized by the rapid hydrolysis of… read more here.
Keywords: natural inhibitors; cholinesterases hydrangea; hydrangea vitro; vitro silico ... See more keywords
Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2017 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2017-0036
Abstract: Accumulating evidence indicates a solid relationship between several enzymes and Alzheimer's disease. Cholinesterases and monoamine oxidases are closely associated with the disease symptomatology and progression and have been tackled simultaneously using several multifunctional ligands. This… read more here.
Keywords: monoamine oxidases; alzheimer disease; disease; cholinesterases monoamine ... See more keywords