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Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase

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Published in 2022 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2022.867587

Abstract: A new series of flexible 5′-norcarbocyclic aza/deaza-purine nucleoside analogs were synthesized from 6-oxybicyclo[3.1.0.]hex-2-ene and pyrazole-containing fleximer analogs of heterocyclic bases using the Trost procedure. The compounds were evaluated as potential inhibitors of E. coli purine… read more here.

Keywords: norcarbocyclic aza; aza deaza; coli purine; deaza purine ... See more keywords