Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.
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DOI: 10.1021/acs.jmedchem.8b00298
Abstract: The design, synthesis, and biological evaluation of a new class of HIV-1 protease inhibitors containing stereochemically defined fused tricyclic polyethers as the P2 ligands and a variety of sulfonamide derivatives as the P2' ligands are… read more here.
Keywords: design synthesis; hiv; protease inhibitors; hiv protease ... See more keywords
Novel Succinate Dehydrogenase Inhibitors Containing Oxime Ester Structures: Design, Synthesis, and Biological Activities
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DOI: 10.1039/d5nj02547h
Abstract: The development of succinate dehydrogenase inhibitors (SDHIs) is crucial for ensuring sustainable food production. This study introduces a novel class of aryl oxime ester derivatives to improve antifungal activity. In vitro experiments... read more here.
Keywords: succinate dehydrogenase; inhibitors containing; dehydrogenase inhibitors; oxime ester ... See more keywords