Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity.
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DOI: 10.1021/acschembio.6b01040
Abstract: To uncover their contrasting mechanisms, antimitotic drugs that inhibit Eg5 (kinesin-5) were analyzed in mixed-motor gliding assays of kinesin-1 and Eg5 motors in which Eg5 "braking" dominates motility. Loop-5 inhibitors (monastrol, STLC, ispinesib, and filanesib)… read more here.
Keywords: microtubule stability; contrasting effects; eg5; inhibitors contrasting ... See more keywords