Probing the Time Dependency of Cyclooxygenase-1 Inhibitors by Computer Simulations.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b01006
Abstract: Time-dependent inhibition of the cyclooxygenases (COX) by a range of nonsteroidal anti-inflammatory drugs has been described since the first experimental assays of COX were performed. Slow tight-binding inhibitors of COX-1 bind in a two-step mechanism… read more here.
Keywords: tight binding; time; inhibitors cox; time dependency ... See more keywords
Flavonoids: Antiplatelet Effect as Inhibitors of COX-1
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27031146
Abstract: Flavonoids are compounds with a benzopyranic structure that exhibits multiple pharmacological activities. They are known for their venotonic activity, but their mechanism of action remains unclear. It is thought that, as this mechanism is mediated… read more here.
Keywords: antiplatelet effect; flavonoids antiplatelet; inhibitors cox; activity ... See more keywords