Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01312
Abstract: KRAS, the most frequently mutated oncogene, plays a predominant role in driving initiation and progression of cancers. Decades of effort to target KRAS using small molecules has been unsuccessful, causing KRAS to be considered an… read more here.
Keywords: directly targeting; inhibitors directly; small molecule; chemistry ... See more keywords