HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
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DOI: 10.1038/s41598-018-25404-w
Abstract: Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program. HSF1 is thought to be regulated by molecular chaperones, including Heat Shock Protein 90 (HSP90).… read more here.
Keywords: hsp90; hsp90 inhibitors; inhibitors disrupt; hsf1 ... See more keywords