Selective Macrocyclic Inhibitors of DYRK1A/B.
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DOI: 10.1021/acsmedchemlett.1c00630
Abstract: Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target of interest due to the roles it plays in both neurological diseases and cancer. We present the development of the first macrocyclic inhibitors of DYRK1A.… read more here.
Keywords: cell; inhibitors dyrk1a; chemistry; selective macrocyclic ... See more keywords