Identification of 11β-HSD1 inhibitors through enhanced sampling methods.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06894f
Abstract: Aminoarylbenzosuberene (AAB) molecules were chosen for in silico analysis to develop effective and more competent 11β-hydroxysteroid dehydrogenase (11β-HSD1) protein inhibitors. The AAB4 molecule was shown to have stronger interactions and binding affinity than standard inhibitors… read more here.
Keywords: enhanced sampling; identification hsd1; hsd1; sampling methods ... See more keywords
The Lethality of [Pazopanib + HDAC Inhibitors] Is Enhanced by Neratinib
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00650
Abstract: Sarcomas are a diverse set of malignancies. For soft tissue sarcomas, the kinase and chaperone inhibitor pazopanib is a standard of care therapeutic. Previously, we demonstrated that HDAC inhibitors enhanced pazopanib lethality against sarcoma and… read more here.
Keywords: pazopanib entinostat; inhibitors enhanced; hdac inhibitors; expression ... See more keywords