Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming.
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DOI: 10.1021/acs.jmedchem.1c00651
Abstract: The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. Inhibition of Factor XIIa (FXIIa), an initiator of the… read more here.
Keywords: mrna display; cyclic peptide; inhibitors fxiia; peptide inhibitors ... See more keywords