Discovery of potent inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage functionalization of 2-(4-(pyridin-2-yl)phenoxy)pyridine analogue.
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DOI: 10.1021/acs.jmedchem.0c00337
Abstract: SIS3 is a specific inhibitor of Smad3 that inhibits the TGFβ1-induced phosphorylation of Smad3. In this article, a variety of SIS3 derivatives were designed and synthesized to discover potential inhibitors against P-glycoprotein-mediated multidrug resistance to… read more here.
Keywords: mediated multidrug; late stage; inhibitors glycoprotein; aided late ... See more keywords
Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia
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DOI: 10.3390/ijms24044140
Abstract: Acute myeloid leukemia (AML) remains an insidious neoplasm due to the percentage of patients who develop resistance to both classic chemotherapy and emerging drugs. Multidrug resistance (MDR) is a complex process determined by multiple mechanisms,… read more here.
Keywords: acute myeloid; myeloid leukemia; inhibitors glycoprotein; natural inhibitors ... See more keywords