Entry Inhibitors of Hepatitis B and D Viruses.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-16-8702-0_12
Abstract: Human hepatitis B virus (HBV) and hepatitis D virus (HDV) cause acute and chronic infections. The latter poses a serious public health threat as it is the major cause of chronic hepatitis, liver failure, cirrhosis,… read more here.
Keywords: hbv; inhibitors hepatitis; entry inhibitors; hdv ... See more keywords
Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.032
Abstract: Herein, we present the design and synthesis of 2(1H)-pyrazinone based HCV NS3 protease inhibitors and show that elongated R3 urea substituents were associated with increased inhibitory potencies over several NS3 protein variants. The inhibitors are… read more here.
Keywords: inhibitors hepatitis; ns3 protease; pyrazinone; pan ns3 ... See more keywords