Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.
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DOI: 10.1021/acs.jmedchem.2c00549
Abstract: Phosphoinositide-3-kinase (PI3K) overexpressed in many tumors is a promising target for cancer therapy. However, due to toxicity from the ubiquitous expression of PI3K in many tissues, the development of PI3K inhibitors with high selectivity and… read more here.
Keywords: pi3k; inhibitors high; high selectivity; cancer ... See more keywords