Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00549
Abstract: Phosphoinositide-3-kinase (PI3K) overexpressed in many tumors is a promising target for cancer therapy. However, due to toxicity from the ubiquitous expression of PI3K in many tissues, the development of PI3K inhibitors with high selectivity and… read more here.
Keywords: pi3k; inhibitors high; high selectivity; cancer ... See more keywords
Discovery of Novel PTP1B Inhibitors by High-throughput Virtual Screening.
Sign Up to like & getrecommendations! Published in 2024 at "Current computer-aided drug design"
DOI: 10.2174/0115734099278007241004105500
Abstract: AIM To Discover novel PTP1B inhibitors by high-throughput virtual screening Background: Type 2 Diabetes is a significant global health concern. According to projections, the estimated number of individuals affected by the condition will reach 578… read more here.
Keywords: high throughput; ptp1b; throughput virtual; ptp1b inhibitors ... See more keywords