Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.10.048
Abstract: In previous work, we described 6-6'-bisindole compounds targeting a hydrophobic pocket on the N-heptad repeat region of viral glycoprotein-41 as effective inhibitors of HIV-1 fusion. Two promising compounds with sub-micromolar IC50's contained a benzoic acid… read more here.
Keywords: characteristics bisindole; investigation molecular; benzoic acid; molecular characteristics ... See more keywords
Novel Compound Inhibitors of HIV-1NL4-3 Vpu
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040817
Abstract: HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate… read more here.
Keywords: novel compound; inhibitors hiv; vpu; compound inhibitors ... See more keywords