Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity
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DOI: 10.1098/rstb.2017.0364
Abstract: A series of hydroxamic acids linked by different lengths to a chiral imidazo-ketopiperazine scaffold were synthesized. The compounds with linker lengths of 6 and 7 carbon atoms were the most potent in histone deacetylase (HDAC)… read more here.
Keywords: inhibitors imidazo; selective hdac1; imidazo ketopiperazine; hdac1 inhibitors ... See more keywords