Design and Evaluation of Potent EGFR Inhibitors through the Incorporation of Macrocyclic Polyamine Moieties into the 4-Anilinoquinazoline Scaffold.
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DOI: 10.1021/acs.jmedchem.8b01612
Abstract: Adenosine triphosphate (ATP)-competitive inhibitors of the epidermal growth factor receptor (EGFR) have provided a significant improvement in the disease outcome of nonsmall cell lung cancer (NSCLC). Unfortunately, some marketed drugs affect a transient beneficial response… read more here.
Keywords: anilinoquinazoline scaffold; macrocyclic polyamine; incorporation macrocyclic; egfr inhibitors ... See more keywords