Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00050
Abstract: Developing selective inhibitors for Janus kinase 1 (JAK1) is a significant focus for improving the efficacy and alleviating the adverse effects in treating immune-inflammatory diseases. Herein, we report the discovery of a series of C-5… read more here.
Keywords: pyrazole; inhibitors janus; selective inhibitors; discovery pyrazole ... See more keywords
Inhibitors of the Janus Kinases: A New Oral Treatment Option for Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Gastroenterology"
DOI: 10.1097/mcg.0000000000001404
Abstract: To the Editor: As the Medical Strategy Head Gastroenterology and Global Medical Lead for Xeljanz ulcerative colitis (UC), Inflammation and Immunology Medical Affairs, at Pfizer Inc., I read with great interest the article by Antonelli… read more here.
Keywords: gastroenterology; ulcerative colitis; janus kinases; inhibitors janus ... See more keywords