Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00481
Abstract: Wee1 is a tyrosine kinase that is highly expressed in several cancer types. Wee1 inhibition can lead to suppression of tumor cell proliferation and sensitization of cells to the effects of DNA-damaging agents. AZD1775 is… read more here.
Keywords: selective wee1; antitumor; myelosuppression; inhibitors led ... See more keywords
Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra01753a
Abstract: Histone deacetylase (HDAC) inhibitors are highly involved in the regulation of many pharmacological responses, which results in anti-inflammatory and anti-cancer effects. In the present work, chemoinformatic analyses were performed to obtain two potent and selective… read more here.
Keywords: hdac6 inhibitors; inhibitors led; selective hdac6; synthesis potent ... See more keywords