Sodium–Glucose Cotransporter 2 Inhibitors and Major COVID-19 Outcomes: Promising Mechanisms, Conflicting Data, and Intriguing Clinical Decisions
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DOI: 10.1007/s13300-020-00942-7
Abstract: Dear Editor, In their anecdotal report, Bossi and colleagues demonstrate that ‘‘off-label’’ use of sodium–glucose cotransporter 2 (SGLT2) inhibitors in three subjects with severe or critical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia without… read more here.
Keywords: sodium glucose; cotransporter inhibitors; covid; inhibitors major ... See more keywords
Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0523
Abstract: Aim: Limitations in available therapies for trypanosomiases indicate the need for improved medicines. Cysteine proteases cruzain and rhodesain are validated targets for treatment of Chagas disease and human African trypanosomiasis. Previous studies reported a benzimidazole… read more here.
Keywords: brucei; major cysteine; trypanosoma brucei; benzimidazole inhibitors ... See more keywords