Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21507
Abstract: Mammalian thioredoxin reductase (TrxR) enzymes are homodimeric flavin proteins sharing a unique yet essential selenocysteine residue at their C‐terminus. TrxRs, together with their endogenous substrate thioredoxins, play a crucial role in regulating diverse cellular redox… read more here.
Keywords: thioredoxin reductase; molecule; inhibitors mammalian; small molecule ... See more keywords
Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase.
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DOI: 10.1021/acs.jmedchem.8b01000
Abstract: The glycolytic enzyme aldolase is an emerging drug target in diseases such as cancer and protozoan infections which are dependent on a hyperglycolytic phenotype to synthesize adenosine 5'-triphosphate and metabolic precursors for biomass production. To… read more here.
Keywords: aldolase; inhibitors mammalian; mammalian glycolytic; bisphosphonate ... See more keywords
Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006701
Abstract: Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in the… read more here.
Keywords: leishmaniasis; inhibitors mammalian; mammalian target; target rapamycin ... See more keywords
Inhibitors of Mammalian Aquaporin Water Channels
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DOI: 10.3390/ijms20071589
Abstract: Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ system. The structural… read more here.
Keywords: inhibitors mammalian; water; water channels; aquaporin water ... See more keywords