Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases
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DOI: 10.1007/s10600-017-1985-4
Abstract: Fucoidan hydrolase inhibitors were discovered for the first time. Metabolites in the aqueous EtOH extract of Fucus evanescens inhibited specifically the activity of enzymes involved in catabolism of brown-alga polysaccharides, i.e., fucoidanases (recombinant FFA from… read more here.
Keywords: metabolites inhibitors; alga metabolites; marine organism; organism fucoidan ... See more keywords
TRAF6 Inhibitors from Marine Compound Library: Pharmacophore, Virtual Screening, Fragment Replacement, ADMET, and Molecular Dynamics
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DOI: 10.3390/md22060260
Abstract: TRAF6 is an E3 ubiquitin ligase that plays a crucial role in cell signaling. It is known that MMP is involved in tumor metastasis, and TRAF6 induces MMP-9 expression by binding to BSG. However, inhibiting… read more here.
Keywords: inhibitors marine; traf6 inhibitors; molecular dynamics; compound library ... See more keywords