Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc04022f
Abstract: Herein, we describe the development of a novel staple with an electrophilic warhead to enable the generation of stapled peptide covalent inhibitors of the p53-MDM2 protein-protein interaction (PPI). The peptide developed showed complete and selective… read more here.
Keywords: covalent inhibitors; targeted covalent; electrophile bearing; mdm2 using ... See more keywords
Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening
Sign Up to like & getrecommendations! Published in 2018 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s182444
Abstract: Background The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the activity of p53 protein… read more here.
Keywords: protein; inhibitors mdm2; p53 interaction; mdm2 p53 ... See more keywords