CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.03.023
Abstract: CDK4/6 inhibitors are among a new generation of therapeutics. Building upon the striking success of the combination of CDK4/6 inhibitors and the hormone receptor antagonist letrozole in breast cancer, many other combinations have recently entered… read more here.
Keywords: may simple; inhibitors mechanism; cdk4; cdk4 inhibitors ... See more keywords
[PARP Inhibitors: From the Mechanism of Action to Clinical Practice].
Sign Up to like & getrecommendations! Published in 2022 at "Acta medica portuguesa"
DOI: 10.20344/amp.13870
Abstract: Repairing damage and errors that occur in the DNA molecule is essential to maintain the integrity of the genome and cell viability. Deficits in DNA repair mechanisms lead to an increased risk of genetic instability… read more here.
Keywords: mechanism action; parp inhibitors; clinical practice; inhibitors mechanism ... See more keywords