Potential acetylcholinesterase inhibitors: molecular docking, molecular dynamics, and in silico prediction
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DOI: 10.1007/s00894-017-3228-9
Abstract: AbstractThis paper deals with molecular modeling of new therapeutic agents for treating the Alzheimer’s disease. The therapeutic line adopted for this study is the cholinergic hypothesis. To modulate positively the cholinergic function through the inhibition… read more here.
Keywords: acetylcholinesterase; docking molecular; acetylcholinesterase inhibitors; inhibitors molecular ... See more keywords
Molecular dynamics and 3D-QSAR studies on indazole derivatives as HIF-1α inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2051745
Abstract: Abstract Hypoxia-inducible factor (HIF) is a transcriptional factor which plays a crucial role in tumour metastasis thereby responsible for development of various forms of cancers. Indazole derivatives have been reported in the literature as potent… read more here.
Keywords: qsar studies; inhibitors molecular; indazole derivatives; molecular dynamics ... See more keywords
Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072201
Abstract: Proteasome inhibitors have shown relevant clinical activity in several hematological malignancies, namely in multiple myeloma and mantle cell lymphoma, improving patient outcomes such as survival and quality of life, when compared with other therapies. However,… read more here.
Keywords: inhibitors molecular; proteasome inhibitors; development; mechanisms resistance ... See more keywords