Binding Modes of Xanthine‐Derived Selective Allosteric Site Inhibitors of MTHFD2
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DOI: 10.1002/open.202300052
Abstract: Abstract Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibitors of MTHFD2 which… read more here.
Keywords: xanthine derivatives; allosteric site; modes xanthine; inhibitors mthfd2 ... See more keywords