Statins and PCSK9 inhibitors: A new lipid-lowering therapy.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173114
Abstract: The clinical benefit of lipid-lowering therapies is to reduce circulating levels of atherogenic particles and to ameliorate the risk of atherosclerotic cardiovascular disease (ASCVD). The completion of two major clinical trials on PCSK9 inhibitors (PCSK9i),… read more here.
Keywords: pcsk9 inhibitors; clinical trials; lipid lowering; therapy ... See more keywords
Factor XIa Inhibitors as New Anticoagulants.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00173
Abstract: With the introduction of thrombin and factor Xa inhibitors to the oral anticoagulant market, significant improvements in both efficacy and safety have been achieved. Early clinical and preclinical data suggest that inhibitors of factor XIa… read more here.
Keywords: factor xia; chemistry; new anticoagulants; inhibitors new ... See more keywords
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2012800118
Abstract: Significance Peptide macrocycles are a promising class of drugs, but their weakness is conformational flexibility: target affinity can be limited by an unfavorable transition from a disordered unbound state to an ordered bound state. We… read more here.
Keywords: new delhi; inhibitors new; metallo lactamase; delhi metallo ... See more keywords
PARP Inhibitors: A New Horizon for Patients with Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061416
Abstract: The introduction of PARP inhibitors (PARPi) in prostate cancer is a milestone and provides a pathway to hope in fighting this disease. It is the first time that drugs, based on the concept of synthetic… read more here.
Keywords: parpi; prostate cancer; new horizon; inhibitors new ... See more keywords
From Naturally-Sourced Protease Inhibitors to New Treatments for Fungal Infections
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Fungi"
DOI: 10.3390/jof7121016
Abstract: Proteases are involved in a broad range of physiological processes, including host invasion by fungal pathogens, and enzymatic inhibition is a key molecular mechanism controlling proteolytic activity. Importantly, inhibitors from natural or synthetic sources have… read more here.
Keywords: naturally sourced; inhibitors new; new treatments; protease inhibitors ... See more keywords