Porcupine Inhibitors: Novel and Emerging Anti-cancer Therapeutics Targeting the Wnt Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105532
Abstract: Porcupine is a constituent of the 19 membered Wnt family with diverse biological features such as cell differentiation, cell proliferation, cell migration, apoptosis, etc. Porcupine is a membrane-bound o-acyltransferase family protein that modulates Wnt protein… read more here.
Keywords: porcupine; porcupine inhibitors; inhibitors novel; emerging anti ... See more keywords
BET inhibitors: a novel epigenetic approach
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx157
Abstract: Epigenetics has been defined as 'the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states.' Currently, several classes of anticancer drugs function at the epigenetic level, including inhibitors of… read more here.
Keywords: bet proteins; inhibitors novel; approach; epigenetic approach ... See more keywords
JAK inhibitors: a novel, safe, and efficacious therapy for pyoderma gangrenosum.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of dermatology"
DOI: 10.1111/ijd.16676
Abstract: BACKGROUND Pyoderma gangrenosum currently lacks standardized therapy. New safer and more efficacious therapies are welcome. AIMS To present two new PG cases treated with JAK inhibitors, adding to the small existing experience METHODS & METHODS:… read more here.
Keywords: inhibitors novel; jak inhibitors; pyoderma gangrenosum; therapy ... See more keywords
Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?
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DOI: 10.3390/antibiotics12010142
Abstract: Resistance to antibiotic treatment developed by bacteria in humans and animals occurs when the microorganisms resist treatment with clinically approved antibiotics. Actions must be implemented to stop the further development of antibiotic resistance and the… read more here.
Keywords: antibiotic resistance; anhydrase inhibitors; carbonic anhydrase; resistance ... See more keywords