Inhibitors of PARP: Number crunching and structure gazing
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121979119
Abstract: Significance PARP is an important target in the treatment of cancers, particularly in patients with breast, ovarian, or prostate cancer that have compromised homologous recombination repair (i.e., BRCA−/−). This review about inhibitors of PARP (PARPi)… read more here.
Keywords: parp number; crunching structure; structure gazing; structure ... See more keywords
Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro
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DOI: 10.3892/mmr.2017.6568
Abstract: It has been confirmed that the inhibitors of poly ADP-ribose polymerF(^9ase-1 (PARP-1) can inhibit the proliferation, apoptosis and invasion of tumor cells. However, the effects of inhibitors of PARP-1 on hepatocellular carcinoma remain to be… read more here.
Keywords: hepatocellular carcinoma; inhibitors parp; bsi 201; hepg2 cells ... See more keywords
Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods
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DOI: 10.7717/peerj.9241
Abstract: Background Research has shown that Poly-ADP-ribose polymerases 1 (PARP-1) is a potential therapeutic target in the clinical treatment of breast cancer. An increasing number of studies have focused on the development of highly selective inhibitors… read more here.
Keywords: revealing selective; mechanisms inhibitors; parp; inhibitors parp ... See more keywords