Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells.
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DOI: 10.1016/j.tox.2018.01.005
Abstract: Previous studies have shown that certain kinase inhibitors are mitochondrial toxicants. In the current investigation, we determined the mechanisms of mitochondrial impairment by the kinase inhibitors ponatinib, regorafenib, and sorafenib in more detail. In HepG2… read more here.
Keywords: kinase inhibitors; inhibitors ponatinib; regorafenib sorafenib; kinase ... See more keywords