Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.103
Abstract: Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is ubiquitously expressed and is regarded as a regulator for various cellular events and signalling pathways. It exists in two isoforms, GSK-3α and GSK-3β and can… read more here.
Keywords: kinase inhibitors; glycogen synthase; kinase; target ... See more keywords
Tyrosinase inhibitors as potential antibacterial agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111892
Abstract: Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses and… read more here.
Keywords: potential antibacterial; antibacterial agents; tyrosinase inhibitors; tyrosinase ... See more keywords
DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02050
Abstract: According to the World Health Organization (WHO), 422 million people are suffering from diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose control to prevent long-term diabetes complications. Unfortunately, current therapies have failed… read more here.
Keywords: therapeutics cell; cell proliferation; potential therapeutics; regeneration ... See more keywords
Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00291
Abstract: Previously, we reported that immunoproteasome (iP)-targeting linear peptide epoxyketones improve cognitive function in mouse models of Alzheimer's disease (AD) in a manner independent of amyloid β. However, these compounds' clinical prospect for AD is limited… read more here.
Keywords: immunoproteasome inhibitors; alzheimer disease; disease; inhibitors potential ... See more keywords
Recent Advances with KDM4 Inhibitors and Potential Applications.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00680
Abstract: The histone lysine demethylase 4 (KDM4) family plays an important role in regulating gene transcription, DNA repair, and metabolism. The dysregulation of KDM4 functions is associated with many human disorders, including cancer, obesity, and cardiovascular… read more here.
Keywords: inhibitors potential; chemistry; potential applications; advances kdm4 ... See more keywords
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00219
Abstract: We describe the synthesis of triazole-containing carboline derivatives and their utility as bromodomain and extra-terminal (BET) inhibitors. A convergent synthetic route permitted the detailed investigation of deuteration and fluorination strategies to reduce clearance while maintaining… read more here.
Keywords: bet; potential treatments; inhibitors potential; bet inhibitors ... See more keywords
Selective TYK2 inhibitors as potential therapeutic agents: a patent review (2019–2021)
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2026927
Abstract: ABSTRACT Introduction Tyrosine kinase 2 (TYK2) is a member of the JAK family class of kinases that is responsible for mediating the immune response to IL-12, IL-23, and IFNα. The therapeutic value of targeting this… read more here.
Keywords: review; inhibitors potential; selective tyk2; tyk2 ... See more keywords
Pan-selectin inhibitors as potential therapeutics for COVID-19 treatment: in silico screening study
Sign Up to like & getrecommendations! Published in 2021 at "Glycobiology"
DOI: 10.1093/glycob/cwab021
Abstract: Abstract Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the globe. The spectrum of disease is broad but among hospitalized patients with COVID-19, respiratory failure from acute respiratory distress syndrome is the leading cause of… read more here.
Keywords: treatment; selectin inhibitors; pan selectin; inhibitors potential ... See more keywords
Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease
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DOI: 10.1371/journal.pone.0262482
Abstract: Based on previous large-scale in silico screening several factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro. In addition to their known anticoagulants activity this potential inhibition could have an additional therapeutic effect on… read more here.
Keywords: evaluation inhibitors; potential inhibitors; inhibitors potential; inhibitors sars ... See more keywords
Topoisomerase Enzyme Inhibitors as Potential Drugs against Cancer: What Makes Them Selective or Dual? - A Review.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220728095619
Abstract: Topoisomerase inhibitors are extensively used in cancer chemotherapy. In the process of identifying novel anticancer compounds, biological evaluations are crucial and include, among others, the use of in silico and in vitro approaches. This work… read more here.
Keywords: cancer; inhibitors potential; enzyme inhibitors; topoisomerase inhibitors ... See more keywords
CAXII inhibitors: Potential sensitizers for immune checkpoint inhibitors in HCC treatment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1052657
Abstract: Hepatocellular carcinoma (HCC) is a lethal malignancy with a lack of effective treatments particularly for the disease at an advanced stage. Even though immune checkpoint inhibitors (ICIs) have made great progress in the treatment of… read more here.
Keywords: checkpoint inhibitors; immune checkpoint; inhibitors potential; caxii inhibitors ... See more keywords